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KMID : 0191120070220050855
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Journal of Korean Medical Science
2007 Volume.22 No. 5 p.855 ~ p.861
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Epstein-Barr Virus, Beta-Catenin, and E-cadherin in Gastric Carcinomas
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Jung In-Mok
Chung Jung-Kee
Kim Young-A
Kim Ji-Eun
Heo Seung-Chul
Ahn Young-Joon
Hwang Ki-Tae
Kim Byeong-Gwan
Lee Kook-Lae
Kim Chul-Woo
Kim Woo-Ho
Chang Mee-Soo
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Abstract
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Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relationship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, betacatenin, and E-cadherin immunohistochemistry, and clinicophatological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplamic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with betacatenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient’s survival (p<0.05). In conclusion, betacatenin activation through nuclear accumulation hardly occurred in EBV-infected gastric carcinomas. The combined immunoexpression pattern of beta-catenin and E-cadherin can be used as a prognostic marker in gastric carcinomas
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KEYWORD
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Stomach Neoplasms, Herpesvirus 4, Human, Beta Catenin, Cadherins, Prognosis
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